RANDOMISED DOUBLE BLIND PLACEBO CONTROLLED STUDY TO EVALUATE THE EFFECT OF CARDIPRO ON ENDOTHELIAL DYSFUNCTION AND BIOMARKERS IN PATIENTS WITH TYPE2 DIABETES MELLITUS.

Abstract

Diabetes mellitus is considered as an important risk factor of cardiovascular disease. Oxidative stress has been implicated as the underlying cause of both macrovascular and microvascular complications associated with type2 diabetes mellitus. Studies have reported that endothelial dysfunction occurs in patients with diabetes much earlier than clinical manifestations of diabetic vascular complications. Endothelial dysfunction is mainly due to accelerated nitric oxide (NO) degradation by reactive oxygen species. Therefore, therapies aimed at reducing oxidative stress may benefit patients with type2 diabetes mellitus and those at risk for developing diabetes.